Research

What is Ibogaine

Ibogaine is a naturally occurring compound found in the roots of the African shrub iboga, and it has been used for centuries in spiritual and healing ceremonies. More recently, it has gained interest from the medical and scientific communities for its potential to treat opioid and cocaine addiction, and research has suggested that it increases signaling of several important molecules within the brain. [1]

Data on Ibogaine Treatment

Clinical observations have reported that a single administration of ibogaine can lead to a significant reduction in opioid withdrawal symptoms and may facilitate sustained abstinence or reduced use over a 12-month period. However, it’s important to note that ibogaine treatment carries risks, including potential cardiotoxic effects, and should only be administered under medical supervision. [2]

Clinical Trials & Studies of Ibogaine

Several studies have explored the therapeutic potential of ibogaine:

• A systematic literature review concluded that ibogaine is an effective intervention for substance use disorders, reducing withdrawal symptoms and cravings. The review also noted potential benefits for depressive and trauma-related symptoms. [3]

• A preliminary trial involving military veterans with traumatic brain injuries found that ibogaine administration led to improvements in depression, anxiety, and overall functioning. [1]

• Dr. Williams and researchers in his lab completed a pioneering research study of the use of ibogaine to treat post-traumatic stress disorder (PTSD) caused by traumatic brain injuries in U.S. Special Operations Forces Veterans. Published in Nature Medicine, researchers found that ibogaine, a plant-based psychoactive compound, when combined with a cardioprotective agent, safely led to improvements in depression, anxiety and functioning among veterans with traumatic brain injuries. [5]

Ongoing research aims to further elucidate ibogaine’s mechanisms of action and its safety profile to determine its viability as a mainstream therapeutic option.

Who Could Benefit from Ibogaine?

Research suggests that ibogaine may offer therapeutic benefits for individuals with:

• Substance Use Disorders (SUD): Ibogaine has been studied for its potential to reduce withdrawal symptoms and cravings associated with opioid dependence. [2]

• Mental Health Conditions: Preliminary studies indicate that ibogaine may alleviate symptoms of depression and anxiety. [3]

• Post-Traumatic Stress Disorder (PTSD): Emerging evidence suggests that ibogaine can reduce PTSD symptoms, particularly in individuals with traumatic brain injuries. [1]

• Neuroregeneration: Ibogaine has been observed to promote neuroplasticity, potentially aiding in brain repair mechanisms. [4]